Endocrine Abstracts

We have previously described how signaling responses for the glucagon-like peptide-1 receptor (GLP-1R), a class B GPCR that plays key roles in metabolic regulation and is a prime type 2 diabetes (T2D) target, are modulated by intracellular membrane trafficking. We have also recently shown that binding to the therapeutic GLP-1R agonist exendin-4 (Exenatide) triggers increased clustering and segregation of biologically active GLP-1Rs into cholesterol-rich plasma membrane nanodom...

Type 2 diabetes is considered a disease of epidemic proportions, its control is important to prevent macro and microvascular complications.This study aims to determine the factors associated with poor glycemic control, defined as HbA1c >7% in type 2 diabetic patients of cardiovascular risk program of the Central Hospital of National Police in ColombiaMethodology: This is a descriptive cross-sectional study, where it is performe...

Introduction: 2 to 3% of the causes of hypoglycemia in the population without diabetes mellitus correspond to tumors of cells other than islets. Below is a rare case of hypoglycemia related to a pleural tumor. Clinical case: A 65-year-old woman with arterial hypertension, psychiatric treatment for confusion and behavioral changes of 6 months of evolution, palpitations and night sweats, loss of 20 kg of weight, several admissions to the emergency room, un...

Background: Pituitary tumours are commonly benign adenomas, accounting for 10-15% of all intracranial neoplasms. Among functioning pituitary tumours, prolactinomas are the most frequently observed in the clinic (about 40%). Dopamine, acting through the dopamine type 2 receptor (Drd2), is the main inhibitor of lactotroph proliferation and prolactin secretion, therefore, these tumours are usually treated with dopaminergic agonists with a high efficiency. However, there is a subs...

Serum prolactin levels increase progressively from birth to adulthood in female and male rats, being higher in females from birth. Although this gradual increase was associated with concomitant maturation of prolactin-releasing and -inhibiting factors, these processes do not fully explain some sex differences observed. In in vitro studies, using lactotrophs in culture, from rats of different ages, in the absence of hypothalamic control, it was shown that the secretion...

Aim: To evaluate the long-term efficacy of percutaneous ethanol injection treatment (PEIT) as an alternative to thyroid surgery in symptomatic thyroid cysts with a structured protocol.Methods: Seventy five subjects (48±12 years; 58% women) with symptomatic benign thyroid cysts relapsed after drainage were included. PEIT was conducted using the established procedure in our hospital, and the initial cyst volume, pain perceived by the patient and sympt...

Aims: The dual burden of tuberculosis (TBC) and diabetes (DM) has attracted much attention in the past decade. Patients with type 2 diabetes have a higher risk of developing pulmonary tuberculosis; moreover, DM co-morbidity in pulmonary TB is associated with poor treatment outcomes. Patients admitted to Internal Medicine (IM) Departments are an ideal setting to analyze the prognostic roll of DM on TBC clinical course.Material and method: The Minimum Basi...

Background: The BRAFV600E mutation is the most common mutation in papillary thyroid carcinoma (PTC). Its presence has been associated with extrathyroid invasion, lymph node metastasis, and tumor recurrence. Recently, assessment of the BRAFV600E mutation status in patients with PTC has been used as a method to predict tumor aggressiveness.Objective: Our aim has been to analyze the prevalence of BRAFV60...

A 69-year-old patient with a history of hysterectomy 18 years ago due to apparent uterine myomatosis, who presents with a clinical picture of 6 months of evolution of a solid suprapubic mass without any other associated symptomatology. Normal vaginal cytology 3 years ago; Menarche at 16 years of age and obstetric history: G1P2V2(Twin).Physical examination: Indurated mass in the suprapubic region, mobile, not painful External atrophic genitalia; Vaginal e...

Introduction: Melanocortin-4 receptor (MC4R) is a G-protein-coupled receptor expressed in regions of the hypothalamus regulating appetite and energy expenditure. Extensive evidence from genetic and biological studies show that MC4R is a key player in the homeostatic regulation of body weight. MC4R loss of function (LoF) variants are the most common cause of monogenic obesity. We have identified 13 heterozygous MC4R variants in patients with obesity at our academic Obesity Cent...